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To investigate the prognosis of myasthenia gravis (MG) in elderly Chinese patients. We carried out a nested case-control study to investigate the influence of various prognostic factors on the outcome of MG patients in the geriatric hospital of Xinhua Hospital. Seventy-six MG patients with a mean age of (73.2±8.2) years were enrolled. All were followed up for more than one year. The outcome was estimated according to clinical response (uplift response or not), and by Kaplan-Meier methods. Prognostic factors were estimated by logistic regression. After a mean follow-up of (31.8±10.8) months, 39 (52.0%) patients had a good prognosis and 37 (48.0%) had a poor prognosis. The median time to the first therapeutic drug failure in cases with good prognosis was (24.0±10.9) months, while the time for cases with poor prognosis was (6.0±3.6) months. Poor prognosis was associated with non-ocular weakness, age at MG onset ≥80 years, need for mechanical ventilation, and receiving immunosuppressants. Elderly myasthenia gravis patients are heterogeneous. An 80-year-old patient with non-ocular weakness is at a high risk for therapeutic drug failure. Aggressive immunosuppressive therapy is recommended for them.Rudolf Polzer
Rudolf Polzer (26 January 1864 – 27 December 1954) was a German physician and writer. He also became the first psychiatrist for the Reichswehr.
Polzer was born in Solnhofen, an island on the edge of the Bay of Elbe (Elbe is one of the two rivers that meet in Hamburg to become the Elbe). From 1871–