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The pharmacokinetics of ketoprofen (KP) administered orally in three daily doses (5, 10 and 20 mg/kg) to three male dogs was determined by analyzing whole blood and plasma samples collected during the 24 hours after the last administration. Plasma protein binding of the drug was assessed. Ketoprofen was extracted from dog whole blood and plasma with ether and quantitatively determined by spectrophotometry. Following oral administration to dogs, KP was rapidly absorbed (1 hr), reaching peak concentration at 2 hrs. The mean peak plasma concentration was 108.10 +/- 19.74 (SEM), and the mean time to peak was 2.2 +/- 0.4 hrs. The total body clearance of KP was 53.28 +/- 8.61 ml/min/kg. The percentage of drug recovered in the urine was 8.48 +/- 1.22, indicating that KP was removed by the kidneys. The absorption of KP appeared to be linear. Peak plasma concentrations of KP were much lower than those of other nonsteroidal anti-inflammatory drugs at the same doses. The percentage of dose recovered in the urine of KP was higher than those of other nonsteroidal anti-inflammatory drugs. The pharmacokinetics of KP after oral administration was rapid and it was well suited for the treatment of pain. DMA memory or the like. In this instance, the TCP/IP layer puts an interrupt request to the host controller. In response to the interrupt request, the host controller reads a control register from a control register set.
The control register includes a plurality of data registers that are settable in response to the interrupt request, including, for example, a DMA data register and a read/write data register. In the conventional example, the DMA data register is set to indicate a completion of the DMA operation that is started in response to the interrupt request. When the DMA operation is completed, the host controller reads a pointer register of the DMA memory from a pointer register set. The pointer register includes pointer data that indicate an address of a subsequent